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Juan Li, PhD, Professor
Date: 2022-05-12, Views: 1915

                                                                           

Research Area

  • Neuropeptide Y receptor ligands design and their application in nanosystem
  • Near-Infrared fluorescent dyes design, synthesis and application

Contact：

Tel：+86-574-86685513，E-mail：lij@nimte.ac.cn

Education background:

2000.10-2004.07   Bachelor, Department of Chemical Pharmaceutics, Shenyang Pharmaceutical University, China

2004.09-2007.07   Master, Department of Pharmaceutical Analysis, Shenyang Pharmaceutical University, China                     

2008.11-2012.09    PhD, Department of Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics/University of Tuebingen, Germany

Work Experience:

2012.10-2014.09    Assistant Professor, Division of Functional Materials and Nano Devices, Ningbo Institute of Material Technology &Engineering, CAS, China

2014.12-2018.12   Associate Professor, Division of Functional Materials and Nano Devices, Ningbo Institute of Material Technology &Engineering, CAS, China

2019.01-2020.11   Project Professor, Cixi Institute of Biomedical Engineering, Ningbo Institute of Material Technology &Engineering, CAS, China

2020.12-now      Professor, Cixi Institute of Biomedical Engineering, Ningbo Institute of Material Technology &Engineering, CAS, China

Representative Publications:

  1. Yanying Li, Yuanbo Pan, Yinjie Wang, Zhenqi Jiang, Ozioma U. Akakuru, Mingli Li, Xianyun Zhang, Bo Yuan, Jie Xing, Lijia Luo, Dan Larhammar, Aiguo Wu, Juan Li(*); A D-peptide ligand of neuropeptide Y receptor Y1 serves as nanocarrier traversing of the blood brain barrier and targets glioma, Nano Today, 2022, 44: 101465.
  2. Yuanbo Pan #, Canxin Xu #, Hongzhang Deng, Qing You, Chenyang Zhao, Yanying Li, Qianqian Gao, Ozioma Udochukwu Akakuru, Juan Li*, Jianmin Zhang*, Aiguo Wu(*), Xiaoyuan Chen(*); Localized NIR-II laser mediated chemodynamic therapy of glioblastoma, Nano Today, 2022, 43: 101435.
  3. Zhenqi Jiang, Bo Yuan, Yinjie Wang, Zhenni Wei, Shan Sun, Ozioma Udochukwu Akakuru, Yong Li, Juan Li (*), Aiguo Wu (*), Near-infrared heptamethine cyanine dye-based nanoscale coordination polymers with intrinsic nucleus-targeting for low temperature photothermal therapy, Nano Today，2020，34：100910.
  4. Zhenqi Jiang, Xiao Han, Yang Du, Yanying Li, Yong Li, Juan Li (*), Jie Tian, (*) and Aiguo Wu (*), Mixed Metal Metal–Organic Frameworks Derived Carbon Supporting ZnFe2O4/C for High-Performance Magnetic Particle Imaging, Nano Letters. 2021, 21, 2730-2737.
  5. Ozioma Udochukwu Akakuru, Chuang Liu, M. Zubair Iqbal (*), Gohar Ijaz Dar, Gao Yang, Kun Qian, Elvis Ikechukwu Nosike, Jie Xing, Zhoujing Zhang, Yanying Li, Juan Li (*) and Aiguo Wu(*), A Hybrid Organo-Nanotheranostic Platform of Superlative Biocompatibility for Near-Infrared-Triggered Fluorescence Imaging and Synergistically Enhanced Ablation of Tumors, Small, 2020, 2002445.
  6. Zhenqi Jiang (#), Yinjie Wang (#), Li Sun, Bo Yuan, Yuchen Tian, Lingchao Xiang, Yanying Li, Yong Li, Juan Li (*), Aiguo Wu (*), Dual ATP and pH responsive ZIF-90 nanosystem with favorable biocompatibility and facile post-modification improves therapeutic outcomes of triple negative breast cancer in vivo, Biomaterials, 2019, 197: 41-50.
  7. Zhenqi Jiang (#), Yuchen Tian (#), Dingying Shan, Yinjie Wang, Ethan Gerhard, Jianbi Xia, Rong Huang, Yan He, Aiguo Li, Jianchao Tang, Huimin Ruan, Yong Li, Jian Yang, Juan Li (*), Aiguo Wu (*), pH protective Y1 receptor ligand functionalized antiphagocytosis BPLP-WPU micelles for enhanced tumor imaging and therapy with prolonged survival time, Biomaterials, 2018, 170: 70-81.
  8. Juan Li (#), Yuchen Tian (#), Dingying Shan, An Gong, Leyong Zeng, Wenzhi Ren, Lingchao Xiang, Ethan Gerhard, Jinshun Zhao, Jian Yang and Aiguo Wu (*). Neuropeptide Y Y1 receptor-mediated biodegradable photoluminescent nanobubbles as ultrasound contrast agents for targeted breast cancer imaging. Biomaterials, 2017, 116: 106-117.
  9. Zhenqi Jiang (#), Bo Yuan (#), Nianxiang Qiu, Yinjie Wang, Li Sun, Zhenni Wei, Yanyin Li, Jianjun Zheng, Yinhua Jin, Yong Li, Shiyu Du, Juan Li (*), Aiguo Wu (*), Manganese-Zeolitic Imidazolate Frameworks-90 with High Blood Circulation Stability for MRI-Guided Tumor Therapy, Nano-Micro Letters, 2019, 11, 61.
  10. Zhenqi Jiang, Yanying Li, Zhenni Wei, Bo Yuan, Yinjie Wang, Ozioma Udochukwu Akakuru, Yong Li, Juan Li (*), Aiguo Wu (*). Pressure-induced amorphous zeolitic imidazole frameworks with reduced toxicity and increased tumor accumulation improves therapeutic efficacy In vivo. Bioactive Materials, 2021, 6: 740-748.
  11. Juan Li (#), Yang Du (#), Zhenqi Jiang, Yuchen Tian, Nianxiang Qiu, Yinjie Wang, Muhammad Zubair lqbal, Menying Hu, Ruifen Zou, Lijia Luo, Shiyu Du, Jie Tian (*), Aiguo Wu (*), Y1 receptor ligand-based nanomicelle as a novel nanoprobe for glioma-targeted imaging and therapy, Nanoscale, 2018, 10: 5845-5851.  
  12. Zhangsen Yu, Yuanzhi Xia, Jie Xing, Zihou Li, Jianjun Zhen, Yinhua Jin, Yuchen Tian, Chuang Liu, Zhenqi Jiang, Juan Li (*), Aiguo Wu (*), Y1-receptor-ligand-functionalized ultrasmall upconversion nanoparticles for tumor targeted trimodality imaging and photodynamic therapy with low toxicity, Nanoscale, 2018, 10: 17038-17052.
  13. Juan Li, Zheyu Shen, Xuehua Ma, Wenzhi Ren, Lingchao Xiang, An Gong, Tian Xia, Junming Guo, Aiguo Wu (*). Neuropeptide Y Y1 receptors meditate targeted delivery of anticancer drug with encapsulated nanoparticles to breast cancer cells with high selectivity and its potential for breast cancer therapy. ACS Applied Materials & Interfaces 2015, 7: 5574-5582.
  14. Yinjie Wang (#), Zhenqi Jiang (#), Bo Yuan, YuchenTian, Lingchao Xiang, Yanying Li, Yong Yang, Juan Li (*), Aiguo Wu (*). Y1 receptor ligand synergized with P-glycoprotein inhibitor improves therapeutic efficacy of multidrug resistant breast cancer. Biomaterials Science, 2019, 7：4748-4757.
  15. Yan Xing (#), Zhenqi Jiang (#), Ozioma Udochukwu Akakuru, Yan He, Aiguo Li, Juan Li (*), Aiguo Wu (*), Mitochondria-targeting zeolitic imidazole frameworks to overcome platinum-resistant ovarian cancer, Colloids and Surfaces B：Biointerfaces, 2020, 189：110837.
  16. Ling Ma (#), Yinjie Wang (#), Shengmin Zhang (#), Xuechen Qian, Nianyu Xue, Zhenqi Jiang, Ozioma Udochukwu Akakuru, Juan Li (*), Youfeng Xu (*), Aiguo Wu (*), Deep Penetration of Targeted Nanobubbles Enhanced Cavitation Effect on Thrombolytic Capacity, Bioconjugate Chemistry, 2019, 31：369-374.
  17. Xuechen Qian(#), Yinjie Wang(#), Youfeng Xu, Ling Ma, Nianyu Xue, Zhenqi Jiang, Yi Cao, Ozioma Udochukwu Akakuru, Juan Li(*), Shengmin Zhang(*) and Aiguo Wu(*), Active targeting nano-scale bubbles enhanced ultrasound cavitation chemotherapy in Y1 receptor-overexpressed breast cancer, Journal of Materials Chemistry B, 2020, 8: 6837.
  18. Linzi Chen(#), Zhenqi Jiang(#), Ozioma Udochukwu Akakuru, Lifei Yang, Juan Li (*), Suya Ma(*), Aiguo Wu (*), Recent progress in the detection and treatment of atherosclerosis by nanoparticles, Materials Today Chemistry 2020, 17: 100280.

Patents:

Applied Patents: 30, including 3 PCT patent (PCT/CN2014/075727), 1 US patent (14/917,256), 1 German patent (112014004133.5);

Authorized patents: CH 710 313 B1 (Switzerland), ZL201310407938.0, ZL 201310318107.6 (China)

Grants:

National Natural Science Foundation of China (No. 81871411, 2019.01-2022.12, PI: Juan Li)

National Natural Science Foundation of China-The Swedish Foundation for International Cooperation in Research and Higher Education Joint Grant (No. 32011530115, 2020.01-2022.12, PI: Juan Li)

National Natural Science Foundation of China (No. 51303196, 2013.01-2016.12, PI: Juan Li)

Special Program for Applied Research on Super Computation of the NSFC-Guangdong Joint Fund (No. U1501501, 2016.01-2017.12, PI: Juan Li)

National Key R&D Program of China (2018YFC0910601, 2018.07-2020.12, Participant)

Youth Innovation Promotion Association Foundation of CAS (No. 2017-2020, PI: Juan Li)

Science Technology Department of Zhejiang Province (No. 2016C33093, 2016.01-2018.12, PI: Juan Li)

Awards:

Emerging Young Scientists of J Mater. Chem. B, Royal Society Chemistry

Excellent Member of Youth Innovation Promotion Association Foundation of CAS

Membership:

International Society for Neuroscience

International Society for Metabolomics

China Anti-Cancer Association

Youth Innovation Promotion Association, CAS